Susan A. Farr, Ph.D.
|Susan A. Farr, Ph.D.|
Professor of Medicine
1997 Kathy VanDyke Graduate Award, University of Missouri- St. Louis.
2001 Gayle A. Olson and Richard D. Olson Prize, Peptides.
Saint Louis University School of Medicine, Department of Internal, Division of Geriatrics, Behavioral Pharmacology Laboratory, 1992 – present
VA Medical Center, St. Louis, MO, Department of Research, Psychoneuropharmacology Laboratory, Research Physiologist ( 1998 – present ), 1992 – present)
Dr. Farr's lab studies learning and memory changes assoicated with aging and diseases such as Alzheimer's. Dr. Farr's laboratory along with her collaborators have developed antisenses that target key proteins in Alzheimer's' disease. In addition, the lab examines various other therapies to combat age-related cognitive changes including antioxidants.
EXAMPLES OF RECENT PUBLICATIONS:
Farr SA, Price TO, Dominguez LJ, Motisi A, Saiano F, Niehoff, ML, Morley, JE, Banks WA, Ercal N, Barbagallo M. Extra virgin olive oil improves learning and memory in SAMP8 mice. JAD 2012: 28, 81-92.
Morley JE, Armbrecht HJ, Farr SA, Kumar VB. The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer’s disease. Biochim Biophys Acta 2012: 1822, 650-6. .
Erickson MA, Niehoff ML, Farr SA, Morley JE, Dillman LA, Lynch KM, Banks WA. Peripheral administration of antisense targeting the amyloid beta protein precursor protein reverse AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain. JAD 2012: 28: 951-60. 83. Morley JE, Farr SA. Hormesis and amyloid-β protein: physiology or pathology? JAD 2012: 29: 487-92.
Morley JE, Farr, SA, Kumar VB, Armbrecht HJ. The SAMP8 mouse: A model to develop therapeutic interventions for Alzheimer’s disease. Curr Pharm Des 2012 18: 1123-30.
Sandoval KE, Farr SA, Banks WA, Crider AM, Morley JE, Witt KA. Somatostatin subtype-4 agonist NNC 26-9100 decreases extracellular and intracellular Aβ(1-42) trimers. Eur J Pharmacol. 2012: 683, 116-24.
Nonaka N, Farr SA, Nakamachi T, Morley JE, Nakamura M, Shioda S, Banks WA. Intranasal administration of PACAP: Uptake by brain and regional brain targeting with cyclodextrins. Peptides 2012 36:168-175.
Farr SA, Price TO, Banks WA, Ercal N, Morley JE. Effect of alpha-lipoic acid on memory, oxidation and lifespan in SAMP8 mice. J Alzheimer’s Dis 2012: 447-455..
Sandoval KE, Farr SA, Banks WA, Crider Am, Morley JE, Witt KA. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 1520:145-156.
Fiorini A., Sultana R, Foster S, Cenini G, Cai J, Klein JB, Farr SA, Niehoff ML, Morley JE, Kumar VB, Allan Butterfield D. Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: A proteomics study.
Armbrecht HJ, Siddiqui AM, Green M, Farr SA, Kumar VB, Banks WA, Patrick P, Shah GN, Morley JE. SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways. Neurobiol Aging 2013: Aug 19 [Epub ahead of print].
Farr SA, Ripley JL, Sultana R, Zhang Z, Niehoff ML, Platt TI, Murphy MP, Morley JE, Kumar V, Butterfield D. Antisense oligonucleotide againts GSK-3B in brain of SAMP8 mice improves learning and memory and decrease oxidative stress; Involvement of transcription factor Nrf2 and implications for Alzheimer's disease. Free Radical Biology and Medicine 2013, In Press.