Ranjit Ray, PhD

Professor of Internal Medicine
Departments of Internal Medicine and Molecular Microbiology & Immunology
Investigator: Liver Center, Saint Louis University, Midwest Regional Center of Excellence (MRCE) for Biodefense

Education
University of Calcutta, India

Fellowship: University of Alabama at Birmingham

SYNOPSIS OF MY RESEARCH WORK

I have worked on various aspects of respiratory and hepatitis viruses for more than 25 years. Currently, I am focusing on hepatitis C virus (HCV) as a major area of my research. My laboratory was the first to report the pleotropic functions and oncogenic potential of HCV core protein. I worked in understanding host-virus interactions and HCV entry employing pseudotypes. My group has defined the role of glycosaminoglycans on hepatocytes as an attachment receptor of HCV. We have shown HCV genotype 1a growth in immortalized human hepatocytes, and for the first time demonstrated that HCV induces autophagy in infected hepatocytes. I have examined a number of immunological aspects of HCV, including innate and humoral immune responses, and dendritic cell maturation. I have conducted research on various basic aspects of HCV funded by NIH, and participated in a number of ancillary studies on multicenter initiated projects including: The Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C, funded by NIDDK), Vaccine Development studies (funded by NIAID), and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (MRCE, funded by NIAID).

Recent Publications (Selected)
  1. Distinct CD55 Isoform Synthesis and Inhibition of Complement-Dependent Cytolysis by Hepatitis C Virus. Kwon YC, Kim H, Meyer K, Di Bisceglie AM, Ray R. Journal of immunology (Baltimore, Md. : 1950). 2016; 197(4):1127-36. PMID: 27357152
  2. Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes. Kwon YC, Bose SK, Steele R, Meyer K, Di Bisceglie AM, Ray RB, Ray R. Journal of virology. 2015; 89(22):11549-56. PMID: 26355082 PMCID: PMC4645669
  3. Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus. Bose SK, Kim H, eyer K, Wolins N, Davidson NO, Ray R. Journal of virology. 2014; 88(8):4195-203. PMID: 24478438 PMCID: PMC3993747
  4. Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis. Kim H, Bose SK, Meyer K, Ray R. Journal of virology. 2014; 88(5):2564-71. PMID: 24352446 PMCID: PMC3958077
  5. Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles. Mazumdar B, Kim H, Meyer K, Bose SK, Di Bisceglie AM, Ray RB, Diamond MS, Atkinson JP, Ray R. Journal of virology. 2013; 87(14):7902-10. PMID: 23658447 PMCID: PMC3700207
  6. Hepatitis C virus suppresses C9 complement synthesis and impairs membrane attack complex function. Kim H, Meyer K, Di Bisceglie AM, Ray R. Journal of virology. 2013; 87(10):5858-67. PMID: 23487461 PMCID: PMC3648158
  7. Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes. Bose SK, Meyer K, Di Bisceglie AM, Ray RB, Ray R. Journal of virology. 2012; 86(24):13621-8. PMID: 23035229 PMCID: PMC3503076
  8. Hepatitis C virus-mediated inhibition of cathepsin S increases invariant-chain expression on hepatocyte surface. Kim H, Mazumdar B, Bose SK, Meyer K, Di Bisceglie AM, Hoft DF, Ray R. Journal of virology. 2012; 86(18):9919-28. PMID: 22761382 PMCID: PMC3446550
  9. Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance. Bose SK, Shrivastava S, Meyer K, Ray RB, Ray R. Journal of virology. 2012; 86(11):6315-22. PMID: 22457523 PMCID: PMC3372214
  10. Hepatitis C virus proteins inhibit C3 complement production. Mazumdar B, Kim H, Meyer K, Bose SK, Di Bisceglie AM, Ray RB, Ray R. Journal of virology. 2012; 86(4):2221-8. PMID: 22171262 PMCID: PMC3302406
  11. Hepatitis C virus E1 envelope glycoprotein interacts with apolipoproteins in facilitating entry into hepatocytes. Mazumdar B, Banerjee A, Meyer K, Ray R. Hepatology (Baltimore, Md.). 2011; 54(4):1149-56. NIHMSID: NIHMS307831 PMID: 21735466 PMCID: PMC3184191
  12. Progress toward development of a hepatitis C vaccine with broad shoulders. Ray R. Science translational medicine. 2011; 3(94):94ps33. PMID: 21813753