Sarah L George, M.D.

Infectious Diseases
Infectious Diseases
Board Cerification
Infectious Diseases
Internal Medicine

1993 Medical College University of Chicago Pritzker School of Medicine
1994 Internship University of Michigan Hospitals
1996 Residency University of Michigan Hospitals
1999 Fellowship University of Iowa - Iowa City

Dr George is analyzing samples collected from a live attenuated dengue vaccine trial in 72 healthy adults. We are analyzing gene expression after vaccination to identify patterns associated with a high-titer multivalent response to dengue and testing whether antigen-specific T follicular helper cell number and cytokine secretion patterns are correlated with memory B cell and plasma cell antibody responses.

Dr. George's lab is focused on Flavivirus biology and immunology, specifically the interactions between a Flavivirus (GB virus C) and Human Immunodeficiency virus (HIV), the effect of GB virus C on the innate immune response, and development of vaccines for pathogenic Flaviviruses, such as dengue.  Current projects focus on: 1) how a GB virus C protein inhibits HIV replication in a human CD4+ T lymphocyte cell line, and how this protein affects the innate immune response, and 2) T cell and innate immune responses which correlate with development of B cell responses after dengue vaccination.

This work is funded by the NIH via the Human Immune Project Consortium and the Institute for Clinical and Translational science.

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