Sarah L George, M.D.
1993 Medical College University of Chicago Pritzker School of Medicine
Dr George is analyzing samples collected from a live attenuated dengue vaccine trial in 72 healthy adults. We are analyzing gene expression after vaccination to identify patterns associated with a high-titer multivalent response to dengue and testing whether antigen-specific T follicular helper cell number and cytokine secretion patterns are correlated with memory B cell and plasma cell antibody responses.
Dr. George's lab is focused on Flavivirus biology and immunology, specifically the interactions between a Flavivirus (GB virus C) and Human Immunodeficiency virus (HIV), the effect of GB virus C on the innate immune response, and development of vaccines for pathogenic Flaviviruses, such as dengue. Current projects focus on: 1) how a GB virus C protein inhibits HIV replication in a human CD4+ T lymphocyte cell line, and how this protein affects the innate immune response, and 2) T cell and innate immune responses which correlate with development of B cell responses after dengue vaccination.
This work is funded by the NIH via the Human Immune Project Consortium and the Institute for Clinical and Translational science.